| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38715063 | Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study |
| Metformin | 📋 | ✍ | ⛔ | | 38484797 | Effects of melatonin and metformin on the ovaries of rats with polycystic ovary syndrome |
| Berberine | 📋 | ✍ | ⛔ | | 38711201 | Berberine attenuates obesity-induced insulin resistance by inhibiting miR-27a secretion |
| Curcumin | 📋 | ✍ | ⛔ | | 38622915 | Multifaceted physiological and therapeutical impact of curcumin on hormone-related endocrine dysfunctions: A comprehensive review |
| Resveratrol | 📋 | ✍ | ⛔ | | 38726423 | The protective role of resveratrol against high glucose-induced oxidative stress and apoptosis in HepG2 cells |
| Melatonin | 📋 | ✍ | ⛔ | | 38730600 | Protective Effects of Melatonin against Carcinogen-Induced Oxidative Damage in the Thyroid |
| Selenium | 📋 | ✍ | ⛔ | | 38714999 | Supplementation with selenium and coenzyme Q10 in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life |
| Magnesium | 📋 | ✍ | ⛔ | | 38271961 | Associations of the magnesium depletion score and magnesium intake with diabetes among US adults: an analysis of the National Health and Nutrition Examination Survey 2011-2018 |
| Quercetin | 📋 | ✍ | ⛔ | | 38637876 | Effects of quercetin on polycystic ovary syndrome in animal models: a systematic review and meta-analysis |
| Genistein | 📋 | ✍ | ⛔ | | 37762565 | Evaluation of Genistein as a Mitochondrial Modulator and Its Effects on Sperm Quality |
| Vitamin C | 📋 | ✍ | ⛔ | | 38010274 | Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 38147737 | Nigella sativa oil restores hormonal levels, and endocrine signals among thyroid, ovarian, and uterine tissues of female Wistar rats following sodium fluoride toxicity |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38399437 | Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Metabolic Modulators in Skeletal Muscle of Rats with an Obesogenic High-Fat Diet |
| Cinnamon | 📋 | ✍ | ⛔ | | 38671840 | Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38707641 | Ginsenosides for the treatment of insulin resistance and diabetes: Therapeutic perspectives and mechanistic insights |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 38674244 | Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study |
| Medicinal Plants | 📋 | | | | 38715699 | A Narrative Review of Herbal Remedies for Managing Hirsutism |
| Fenugreek | 📋 | ✍ | ⛔ | | 38628109 | Withania somnifera and Trigonella foenum-graecum as ingredients of testosterone-boosting supplements: Possible clinical implications |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38699871 | Alpha-Lipoic Acid Induces Adipose Tissue Browning through AMP-Activated Protein Kinase Signaling in Vivo and in Vitro |
| Vitamin E | 📋 | ✍ | ⛔ | | 38534308 | Vitamin E intake and prevalence rates of thyroid dysfunction and autoimmune thyroiditis: A cross-sectional analysis of NHANES data |
| DHEA | 📋 | ✍ | ⛔ | | 36982376 | DHEA and Its Metabolites Reduce the Cytokines Involved in the Inflammatory Response and Fibrosis in Primary Biliary Cholangitis |
| Zinc | 📋 | ✍ | ⛔ | | 38258780 | The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats |
| Astaxanthin | 📋 | ✍ | ⛔ | | 37874168 | Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple-blind randomized clinical trial |
| Mulberry | 📋 | | ⛔ | | 38612872 | Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays |
| EGCG | 📋 | ✍ | ⛔ | | 38067561 | (-)-Epigallocatechin-3-Gallate Reduces Perfluorodecanoic Acid-Exacerbated Adiposity and Hepatic Lipid Accumulation in High-Fat Diet-Fed Male C57BL/6J Mice |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38107449 | Flavonoid from Moringa oleifera leaves revisited: A review article on in vitro, in vivo, and in silico studies of antidiabetic insulin-resistant activity |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 37697053 | Do "testosterone boosters" really increase serum total testosterone? A systematic review |
| Fish Oil | 📋 | ✍ | ⛔ | | 38414818 | Differential effects of fish-oil and cocoa-butter based high-fat/high-sucrose diets on endocrine pancreas morphology and function in mice |
| Cocoa | 📋 | ✍ | ⛔ | | 38674244 | Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study |
| CoQ10 | 📋 | ✍ | ⛔ | | 38714999 | Supplementation with selenium and coenzyme Q10 in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38078918 | The effect of ellagic acid on sex hormones and miRNA-21 expression in rats with polycystic ovary syndrome |
| Ashwagandha | 📋 | ✍ | ⛔ | | 38628109 | Withania somnifera and Trigonella foenum-graecum as ingredients of testosterone-boosting supplements: Possible clinical implications |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 37599855 | Phytoconstituents from Urtica dioica (stinging nettle) of Sikkim Himalaya and their molecular docking interactions revealed their nutraceutical potential as α-amylase and α-glucosidase inhibitors |
| L-Carnitine | 📋 | ✍ | ⛔ | | 37929031 | Ameliorating effects of L-carnitine and synbiotic co-supplementation on anthropometric measures and cardiometabolic traits in women with obesity: a randomized controlled clinical trial |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 38309487 | In-depth investigation of the therapeutic effect of Tribulus terrestris L. on type 2 diabetes based on intestinal microbiota and feces metabolomics |
| Anthocyanins | 📋 | ✍ | ⛔ | | 38155940 | Gooseberry anthocyanins alleviate insulin resistance by regulating ceramide metabolism in high fat diet mice |
| Micronutrients | 📋 | | ⛔ | | 38242137 | Polycystic ovary syndrome and its management: In view of oxidative stress |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37841396 | The effects of N-acetylcysteine supplement on metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis |
| Naringenin | 📋 | ✍ | ⛔ | | 38009056 | Naringenin alleviates the excessive lipid deposition of polycystic ovary syndrome rats and insulin-resistant adipocytes by promoting PKGIα |
| Phytochemicals | 📋 | | | | 38674046 | Promising Approaches in Plant-Based Therapies for Thyroid Cancer: An Overview of In Vitro, In Vivo, and Clinical Trial Studies |
| Thymoquinone | 📋 | | ⛔ | | 38125651 | Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced obese rats |
| Ginseng | 📋 | ✍ | ⛔ | | 36649918 | Korean Ginseng Berry Extract Enhances the Male Steroidogenesis Enzymes In Vitro and In Vivo |
| Hesperidin | 📋 | ✍ | ⛔ | | 38234970 | Promising influences of hesperidin and hesperetin against diabetes and its complications: a systematic review of molecular, cellular, and metabolic effects |
| Luteolin | 📋 | ✍ | ⛔ | | 38705425 | Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2 |
| Fucoidan | 📋 | ✍ | ⛔ | | 35170612 | Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats |
| Kudzu Root | 📋 | ✍ | ⛔ | | 37802808 | [Effect and mechanism of Puerariae Lobatae Radix in alleviating insulin resistance in T2DM db/db mice based on intestinal flora] |
| Pomegranate | 📋 | | ⛔ | | 38038001 | Protective Effect of Hydroalcoholic Extract of Punica granatum Leaves on High Fructose Induced Insulin Resistance in Experimental Animals |
| Puerarin | 📋 | ✍ | ⛔ | | 38668725 | Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages |
| Saffron | 📋 | ✍ | ⛔ | | 37324874 | Comparison of the effect of saffron, crocin, and safranal on serum levels of oxidants and antioxidants in diabetic rats: A systematic review and meta-analysis of animal studies |
| Ginger | 📋 | ✍ | ⛔ | | 38671840 | Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders |
| Pterostilbene | 📋 | ✍ | ⛔ | | 37432144 | Pterostilbene Attenuates High-Intensity Swimming Exercise-Induced Glucose Absorption Dysfunction Associated with the Inhibition of NLRP3 Inflammasome-Induced IECs Pyroptosis |
| Aloe Vera | 📋 | ✍ | ⛔ | | 37969667 | Effect of aloe vera juice on type 2 diabetes mellitus among Indian patients |
| Blueberry | 📋 | ✍ | ⛔ | | 35630771 | Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties |
| Gallic Acid | 📋 | | ⛔ | | 37255787 | Ameliorative effects of gallic acid on GLUT-4 expression and insulin resistance in high fat diet-induced obesity animal model mice, Mus musculus |
| Apigenin | 📋 | ✍ | ⛔ | | 38481798 | Apigenin targets fetuin-A to ameliorate obesity-induced insulin resistance |
| Licorice Root | 📋 | ✍ | ⛔ | | 35209016 | Novel Evidence-Based Combination of Plant Extracts with Multitarget Mechanisms of Action for the Elimination of Hot Flashes during Menopause |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 38674244 | Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38611359 | Sulforaphane Ameliorates High-Fat-Diet-Induced Metabolic Abnormalities in Young and Middle-Aged Obese Male Mice |
| TUDCA | 📋 | ✍ | ⛔ | | 36564463 | The bile acid TUDCA reduces age-related hyperinsulinemia in mice |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38053727 | Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 35523954 | Time-of-day dependent effect of proanthocyanidins on adipose tissue metabolism in rats with diet-induced obesity |
| Maitake Mushrooms | 📋 | | ⛔ | | 35170606 | Effects of alkaloid-rich extracts obtained from Grifola frondosa on gut microbiota and glucose homeostasis in rats |
| Probiotics | 📋 | ✍ | ⛔ | | 38421576 | Gut Microbiota and Polycystic Ovary Syndrome (PCOS): Understanding the Pathogenesis and the Role of Probiotics as a Therapeutic Strategy |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 37447160 | Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha |
| Polyphenols | 📋 | | | | 38726403 | Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review |
| Astragalosides | 📋 | ✍ | ⛔ | | 38439832 | A systematic review of astragaloside IV effects on animal models of diabetes mellitus and its complications |
| Black Cohosh | 📋 | ✍ | ⛔ | | 37192826 | Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis |
| Chrysin | 📋 | ✍ | ⛔ | | 36677645 | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
| Food | 📋 | | | | 38388374 | Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38430822 | A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndrome |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 34568497 | A Review on Therapeutic Effects of Labisia pumila on Female Reproductive Diseases |
| Silymarin | 📋 | ✍ | ⛔ | | 38396727 | Silymarin Reduced Insulin Resistance in Non-Diabetic Women with Obesity |
| Taurine | 📋 | ✍ | ⛔ | | 38117455 | Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway |
| Coconut Oil | 📋 | | ⛔ | | 38106629 | Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats |
| Crocin | 📋 | ✍ | ⛔ | | 37982317 | Crocin Inhibits Orbital Fibroblasts Fibrosis in Thyroid-Associated Ophthalmopathy |
| Daidzein | 📋 | ✍ | ⛔ | | 36474573 | Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 37051424 | Investigating the Role of EPA and DHA on Cellular Oxidative Stress; Profiling Antidiabetic and Antihypertensive Potential |
| Flaxseed | 📋 | ✍ | ⛔ | | 38063410 | The efficacy of Linum usitatissimum seeds to inhibit estrogen receptor as a natural therapy for PCOS: An in silico and in vitro analysis |
| Goji Berry | 📋 | ✍ | ⛔ | | 38642822 | Lycium barbarum polysaccharides attenuate nonylphenol and octylphenol-induced oxidative stress and neurotransmitter disorders in PC-12 cells |
| Roselle | 📋 | ✍ | ⛔ | | 37314593 | The Phytoestrogenic Effect of Hibiscus sabdariffa Involves Estrogen Receptor α in Ovariectomized Wistar Rats |
| Sage | 📋 | ✍ | ⛔ | | 37489230 | The Effect of Salvia Officinalis on Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis |
| Salidroside | 📋 | | | | 37576042 | Salidroside alleviates diet-induced obesity and insulin resistance by activating Nrf2/ARE pathway and enhancing the thermogenesis of adipose tissues |
| Silibinin | 📋 | ✍ | | | 38726421 | Silibinin as a promising treatment for diabetes: Insights into behavioral and metabolic changes in an animal model |
| Stevia | 📋 | ✍ | ⛔ | | 37488560 | Stevia (Stevia rebaudiana) extract ameliorates insulin resistance by regulating mitochondrial function and oxidative stress in the skeletal muscle of db/db mice |
| Walnut | 📋 | | ⛔ | | 35708635 | Walnut Meal Extracts Rich In Polyphenols Mitigate Insulin Resistance and Modulate Gut Microbiota in High Fat Diet-Fed Rats |
| Baicalin | 📋 | ✍ | ⛔ | | 38203600 | The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38611884 | The Lipophilic Extract from Ginkgo biloba L. Leaves Promotes Glucose Uptake and Alleviates Palmitate-Induced Insulin Resistance in C2C12 Myotubes |
| L-Arginine | 📋 | ✍ | ⛔ | | 38004100 | Arginine and Lysine Supplementation Potentiates the Beneficial β-Hydroxy ß-Methyl Butyrate (HMB) Effects on Skeletal Muscle in a Rat Model of Diabetes |
| Lycopene | 📋 | ✍ | ⛔ | | 37125846 | The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study) |
| Mangiferin | 📋 | | ⛔ | | 35088781 | The management of diabetes mellitus by mangiferin: advances and prospects |
| NMN | 📋 | ✍ | ⛔ | | 38703507 | Alleviation of hepatic insulin resistance and steatosis with NMN via improving endoplasmic reticulum-Mitochondria miscommunication in the liver of HFD mice |
| Nobiletin | 📋 | ✍ | | | 35522926 | Hypoglycemic Effect of Nobiletin via Regulation of Islet β-Cell Mitophagy and Gut Microbiota Homeostasis in Streptozocin-Challenged Mice |
| Oleuropein | 📋 | | | | 36647430 | Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 36647430 | Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 37697053 | Do "testosterone boosters" really increase serum total testosterone? A systematic review |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38637405 | Ameliorative effect of ferulic acid on thyroid dysfunction against propyl-thiouracil induced hypothyroid rats |
| Guava | 📋 | | ⛔ | | 34899946 | Hypoglycemic and Hepatoprotective Effects of Dried and Rice-Fried Psidium guajava Leaves in Diabetic Rats |
| Hesperetin | 📋 | | | | 38234970 | Promising influences of hesperidin and hesperetin against diabetes and its complications: a systematic review of molecular, cellular, and metabolic effects |
| Iodine | 📋 | ✍ | ⛔ | | 38248457 | Iodine Promotes Glucose Uptake through Akt Phosphorylation and Glut-4 in Adipocytes, but Higher Doses Induce Cytotoxic Effects in Pancreatic Beta Cells |
| Kaempferol | 📋 | ✍ | ⛔ | | 38466634 | Kaempferol alleviates adipose tissue inflammation and insulin resistance in db/db mice by inhibiting the STING/NLRP3 signaling pathway |
| Phytoestrogens | 📋 | | ⛔ | | 37159774 | Role of Phytoestrogen in Menopausal Women With Depressive Symptoms: A Consecutive Case Series Study |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 37115092 | Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification |
| Spirulina | 📋 | ✍ | ⛔ | | 36598187 | A randomized, double-blind placebo-controlled add-on trial to assess the efficacy, safety, and anti-atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 38599178 | Ganoderma lucidum and Hypericum perforatum exhibit anti-inflammatory, antioxidant and anti-androgen effect in rat model of experimental polycystic ovarian syndrome |
| Whey Protein | 📋 | ✍ | ⛔ | | 38076400 | Whey Protein Supplementation and Type 2 Diabetes Mellitus Risk Factors: An Umbrella Systematic Review of Randomized Controlled Trials |
| Angelica | 📋 | ✍ | ⛔ | | 37639812 | The efficacy and mechanism of Angelica sinensis (Oliv.) Diels root aqueous extract based on RNA sequencing and 16S rDNA sequencing in alleviating polycystic ovary syndrome |
| Bee Propolis | 📋 | ✍ | ⛔ | | 37658679 | The effects of propolis supplementation on high-sensitivity C-reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple-blinded, placebo-controlled clinical trial |
| Bitter Melon | 📋 | ✍ | ⛔ | | 37009042 | Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study |
| Cannabidiol | 📋 | ✍ | ⛔ | | 37933286 | The pharmacology and therapeutic role of cannabidiol in diabetes |
| Chamomile | 📋 | ✍ | ⛔ | | 37465426 | Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome |
| Coconut | 📋 | | ⛔ | | 36407391 | Regulation of male sex hormones strongly heightens copulation behavior indices in rat's model administered Cocos nucifera husks extract |
| Coffee | 📋 | ✍ | ⛔ | | 37351106 | Effect of coffee consumption on thyroid function: NHANES 2007-2012 and Mendelian randomization |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 37051424 | Investigating the Role of EPA and DHA on Cellular Oxidative Stress; Profiling Antidiabetic and Antihypertensive Potential |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 37694196 | Comparison of the Effect of Fennel and Evening Primrose Oil on Menopausal Problems and Hormonal Levels: A Randomized Controlled Trial |
| Flavonoids | 📋 | | ⛔ | | 37036026 | Bioactivity and mechanisms of flavonoids in decreasing insulin resistance |
| Gingerol | 📋 | ✍ | | | 36557312 | Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications |
| Holy Basil | 📋 | ✍ | ⛔ | | 37141281 | Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 37495431 | Effect of a lavender essential oil and sleep hygiene protocol on insomnia in postmenopausal women: A pilot randomized clinical trial |
| Rutin | 📋 | ✍ | ⛔ | | 37289414 | Rutin, Puerarin and Silymarin Regulated Aluminum-Induced Imbalance of Neurotransmitters and Metal Elements in Brain of Rats |
| Soy | 📋 | ✍ | ⛔ | | 38474777 | Royal Jelly and Fermented Soy Extracts-A Holistic Approach to Menopausal Symptoms That Increase the Quality of Life in Pre- and Post-menopausal Women: An Observational Study |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 37198280 | Effects of folic acid supplementation in pregnant mice on glucose metabolism disorders in male offspring induced by lipopolysaccharide exposure during pregnancy |
| Wormwood | 📋 | ✍ | ⛔ | | 38485514 | The effect of Artemisia annua L. aqueous and methanolic extracts on insulin signaling in liver of HFD/STZ diabetic mice |
| Andrographis | 📋 | ✍ | ⛔ | | 37878369 | Andrographis paniculata (Burm. f.) Nees extract ameliorates insulin resistance in the insulin-resistant HepG2 cells via GLUT2/IRS-1 pathway |
| Black Tea | 📋 | ✍ | ⛔ | | 37083054 | Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice |
| Caffeine | 📋 | ✍ | ⛔ | | 37088693 | Chlorogenic Acid and Caffeine in Coffee Restore Insulin Signaling in Pancreatic Beta Cells |
| Coptis Chinensis | 📋 | | ⛔ | | 34457027 | Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Coptis chinensis Franchin Polycystic Ovary Syndrome |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 38532480 | Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway |
| Fisetin | 📋 | ✍ | ⛔ | | 34298098 | Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome |
| Frankincense | 📋 | ✍ | ⛔ | | 35871254 | Frankincense extract protects against testicular damage through augmentation of antioxidant defense mechanisms and modulation of apoptotic genes expression |
| Green Tea | 📋 | ✍ | ⛔ | | 37083054 | Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice |
| Nicotinamide | 📋 | ✍ | ⛔ | | 35684021 | A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD + Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial |
| Olive Oil | 📋 | ✍ | ⛔ | | 38084993 | Synergistic Action of Virgin Coconut Oil and Clomiphene in Reversing Endocrine Dysregulation in Letrozole-Model of Polycystic Ovarian Syndrome in Rats: Role of Nrf2/HMOX-1 Pathway |
| Piperine | 📋 | ✍ | ⛔ | | 38038344 | Piperine Attenuates Bmal1-Mediated Glucose Metabolism Disorder in a Trpv1-Dependent Manner in HepG2 Cells |
| Tangeretin | 📋 | | | | 35665223 | Effects of 4-Week Tangeretin Supplementation on Cortisol Stress Response Induced by High-Intensity Resistance Exercise: A Randomized Controlled Trial |
| Vitamin A | 📋 | ✍ | ⛔ | | 36303869 | The relationship between thyroid disorders and vitamin A.: A narrative minireview |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 37894898 | Vitamin B12-Induced Autophagy Alleviates High Glucose-Mediated Apoptosis of Islet β Cells |
| Almond | 📋 | | ⛔ | | 36963852 | Premeal almond load decreases postprandial glycaemia, adiposity and reversed prediabetes to normoglycemia: A randomized controlled trial |
| Asiatic Acid | 📋 | | | | 32003703 | Mitigating Perspectives of Asiatic Acid in the Renal Derangements of Streptozotocin-Nicotinamide Induced Diabetic Rats |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 37693081 | Effect of β-sitosterol on insulin resistance & protein expression of insulin signalling molecules in quadriceps muscle of high fat diet-induced type-2 diabetic rats |
| Chokeberry | 📋 | ✍ | ⛔ | | 35739998 | Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome |
| Chromium | 📋 | ✍ | ⛔ | | 38228168 | Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance |
| Cinnamaldehyde | 📋 | | | | 36145160 | A Composition of Phytonutrients for Glycemic and Weight Management |
| Cordyceps | 📋 | ✍ | ⛔ | | 38316217 | Multi-omics reveals the testosterone promotion effect mechanism of Cordyceps Sobolifera on Leydig cells |
| Diosgenin | 📋 | | | | 38371502 | Fenugreek derived diosgenin as an emerging source for diabetic therapy |
| Diosmin | 📋 | ✍ | ⛔ | | 36934613 | Diosmin exerts hepatoprotective and antihyperglycemic effects against sodium arsenite-induced toxicity through the modulation of oxidative stress and inflammation in mice |
| Eugenol | 📋 | | | | 36829079 | Effect of eugenol on lipid profile, oxidative stress, sex hormone, liver injury, ovarian failure, and expression of COX-2 and PPAR-α genes in a rat model of diabetes |
| Fennel | 📋 | ✍ | ⛔ | | 37694196 | Comparison of the Effect of Fennel and Evening Primrose Oil on Menopausal Problems and Hormonal Levels: A Randomized Controlled Trial |
| Garlic | 📋 | ✍ | ⛔ | | 37385425 | Influence of Garlic on the Glycemic Control and Lipid Profile in Animals with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis |
| Ginger extract | 📋 | ✍ | ⛔ | | 36297069 | Ginger Root Extract Improves GI Health in Diabetic Rats by Improving Intestinal Integrity and Mitochondrial Function |
| HMB | 📋 | ✍ | ⛔ | | 38004100 | Arginine and Lysine Supplementation Potentiates the Beneficial β-Hydroxy ß-Methyl Butyrate (HMB) Effects on Skeletal Muscle in a Rat Model of Diabetes |
| Hydroxytyrosol | 📋 | | | | 37219732 | The effects of hydroxytyrosol on Prdx6 and insulin expression in diabetic rat pancreases |
| Indian Gooseberry | 📋 | | ⛔ | | 38590294 | Antidiabetic effectiveness of Phyllanthus niruri bioactive compounds via targeting DPP-IV |
| Isoflavones | 📋 | ✍ | ⛔ | | 38590945 | Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review) |
| Schisandra | 📋 | ✍ | ⛔ | | 33688367 | Evaluation of Beneficial and Adverse Effects of a Diet Supplemented with Schisandrae Fructus Seed Ethanol Extract on Lipid and Glucose Metabolism in Normal and Hypercholesterolemic/Hyperglycemic Mice |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 38460232 | Exploring the potential anti-thyroid activity of Acetyl-L-carnitine: Lactoperoxidase inhibition profile, iodine complexation and scavenging power against H2O2. Experimental and theoretical studies |
| Avocado | 📋 | ✍ | ⛔ | | 38661065 | Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats |
| Biochanin A | 📋 | | | | 37230376 | Biochanin-A attenuates DHEA-induced polycystic ovary syndrome via upregulation of GDF9 and BMP15 signaling in vivo |
| Blackcurrant | 📋 | ✍ | ⛔ | | 37893207 | Blackcurrant Anthocyanins Improve Blood Lipids and Biomarkers of Inflammation and Oxidative Stress in Healthy Women in Menopause Transition without Changing Body Composition |
| Capsaicin | 📋 | ✍ | ⛔ | | 36691893 | Capsaicin ameliorates diet-induced disturbances of glucose homeostasis and gut microbiota in mice associated with the circadian clock |
| Chlorella | 📋 | ✍ | ⛔ | | 32957734 | Chlorella sorokiniana Dietary Supplementation Increases Antioxidant Capacities and Reduces Ros Release in Mitochondria of Hyperthyroid Rat Liver |
| Cornus | 📋 | | | | 36696645 | The effect of Cornus mas fruit extract on vasomotor symptoms and sex hormones in postmenopausal women: a randomized, double-blind, clinical trial |
| Cranberry | 📋 | ✍ | ⛔ | | 38542695 | The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Emodin | 📋 | | ⛔ | | 37927413 | Emodin treatment of papillary thyroid cancer cell lines in vitro inhibits proliferation and enhances apoptosis via downregulation of NF‑κB and its upstream TLR4 signaling |
| Folate | 📋 | ✍ | ⛔ | | 37563586 | Folate deficiency may increase the risk for elevated TSH in patients with type 2 diabetes mellitus |
| GABA | 📋 | ✍ | ⛔ | | 38256069 | Anti-Obesity Effects of GABA in C57BL/6J Mice with High-Fat Diet-Induced Obesity and 3T3-L1 Adipocytes |
| Grape | 📋 | | ⛔ | | 31912105 | Red grape juice protects the rat thyroid gland against hypercholesterolemic changes. Ultrastructural and biochemical evidences |
| Graviola | 📋 | ✍ | ⛔ | | 36836708 | Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties |
| Honey | 📋 | ✍ | ⛔ | | 37809953 | Pancreatic regenerative potential of manuka honey evidenced through pancreatic histology and levels of transcription factors in diabetic rat model |
| Mangosteen | 📋 | ✍ | ⛔ | | 36655319 | Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model |
| Minerals | 📋 | | | | 37887373 | The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation |
| Naringin | 📋 | ✍ | ⛔ | | 37592777 | Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats |
| Oats | 📋 | | ⛔ | | 35004803 | As a Staple Food Substitute, Oat and Buckwheat Compound Has Health-Promoting Effects for Diabetic Rats |
| Onion | 📋 | ✍ | ⛔ | | 35745673 | Quercetin-Rich Extracts from Onions ( Allium cepa) Play Potent Cytotoxicity on Adrenocortical Carcinoma Cell Lines, and Quercetin Induces Important Anticancer Properties |
| Papaya | 📋 | ✍ | ⛔ | | 37111148 | Characterization of Green and Yellow Papaya ( Carica papaya) for Anti-Diabetic Activity in Liver and Myoblast Cells and Wound-Healing Activity in Fibroblast Cells |
| Prebiotics | 📋 | ✍ | ⛔ | | 36275023 | Efficacy evaluation of probiotics combined with prebiotics in patients with clinical hypothyroidism complicated with small intestinal bacterial overgrowth during the second trimester of pregnancy |
| Quinoa | 📋 | | ⛔ | | 37991345 | Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways |
| Raspberry | 📋 | ✍ | ⛔ | | 35421887 | Effects of red raspberry polyphenols and metabolites on the biomarkers of inflammation and insulin resistance in type 2 diabetes: a pilot study |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38599178 | Ganoderma lucidum and Hypericum perforatum exhibit anti-inflammatory, antioxidant and anti-androgen effect in rat model of experimental polycystic ovarian syndrome |
| Rosemary | 📋 | ✍ | ⛔ | | 35011728 | Carnosic Acid Attenuates the Free Fatty Acid-Induced Insulin Resistance in Muscle Cells and Adipocytes |
| Spikenard | 📋 | ✍ | ⛔ | | 29630449 | Nardostachys jatamansi DC Extract Alleviates Insulin Resistance and Regulates Glucose Metabolism in C57BL/KsJ-db/db Mice Through the AMP-Activated Protein Kinase Signaling Pathway |
| Strawberry | 📋 | ✍ | ⛔ | | 37569180 | Antidiabetic, Antioxidative and Antihyperlipidemic Effects of Strawberry Fruit Extract in Alloxan-Induced Diabetic Rats |
| Theaflavins | 📋 | ✍ | | | 37893758 | The Effect of Theaflavins on the Gut Microbiome and Metabolites in Diabetic Mice |
| Turmeric | 📋 | ✍ | ⛔ | | 38613362 | Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 34512411 | Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia |
| Vitex | 📋 | ✍ | ⛔ | | 38075075 | Vitex agnus castus effects on hyperprolactinaemia |
| Andrographolide | 📋 | | | | 36685073 | Dual actions of gallic acid and andrographolide trigger AdipoR1 to stimulate insulin secretion in a streptozotocin-induced diabetes rat model |
| Argan Oil | 📋 | ✍ | ⛔ | | 29299990 | Aqueous Extract of Argania spinosa L. Fruits Ameliorates Diabetes in Streptozotocin-Induced Diabetic Rats |
| Asafoetida | 📋 | ✍ | ⛔ | | 37655000 | "Ferula assa-foetida L" or "Foeniculum vulgare"? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded |
| Barley | 📋 | ✍ | ⛔ | | 36537611 | A comparison between partially peeled hulless barley and whole grain hulless barley: beneficial effects on the regulation of serum glucose and the gut microbiota in high-fat diet-induced obese mice |
| Betaine | 📋 | ✍ | ⛔ | | 38417550 | Dietary Betaine Improves Glucose Metabolism in Obese Mice |
| Blackberry | 📋 | | ⛔ | | 37280499 | Effect of anthocyanin-rich blackberry juice on endoplasmic reticulum stress in streptozotocin-induced diabetic rats |
| Butyrate | 📋 | | ⛔ | | 37996797 | Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS |
| Calcium | 📋 | ✍ | ⛔ | | 35088227 | Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome |
| Cardamom | 📋 | ✍ | ⛔ | | 37403247 | Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil-induced hypothyroidism male BALB/c mice |
| Catechins | 📋 | | | | 36501092 | Effects of Ingesting Both Catechins and Chlorogenic Acids on Glucose, Incretin, and Insulin Sensitivity in Healthy Men: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial |
| Date | 📋 | | ⛔ | | 36125886 | Tiger nut (Cyperus esculentus L.) and date palm (Phoenix dactylifera L.) fruit blend mitigates hyperglycemia, insulin resistance and oxidative complications in type-2 diabetes models |
| Fig | 📋 | | ⛔ | | 38692894 | Antidiabetic Effect of Fig Seed Oil in Rats with Diabetes Induced by Streptozotocin |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 36433633 | The effects of flaxseed or its oil supplementations on polycystic ovary syndrome: A systematic review of clinical trials |
| Icariin | 📋 | ✍ | | | 37269973 | Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome |
| L-Citrulline | 📋 | ✍ | ⛔ | | 38002262 | Supplementing L-Citrulline Can Extend Lifespan in C. elegans and Attenuate the Development of Aging-Related Impairments of Glucose Tolerance and Intestinal Barrier in Mice |
| Lemon Balm | 📋 | ✍ | ⛔ | | 38303002 | Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats |
| Lotus | 📋 | | ⛔ | | 37693992 | Hypoglycemic Effect of Nelumbo Nucifera Seed Extract on GLUT-4 mRNA and GLUT-4 Protein in Streptozotocin-Induced Diabetic Rats |
| Maca Root | 📋 | ✍ | ⛔ | | 36593713 | Efficacy and Safety of Maca ( Lepidium meyenii) in Patients with Symptoms of Late-Onset Hypogonadism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Mango Leaf | 📋 | | ⛔ | | 31914140 | Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats |
| Myrrh | 📋 | ✍ | ⛔ | | 36825257 | Pharmacological Studies on the Antidiabetic, Antioxidant, and Antimicrobial Efficacies of Commiphora myrrha Resin in Streptozotocin-Induced Diabetes in Rats: A Preclinical Study |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 37373163 | Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside |
| Okra | 📋 | | ⛔ | | 37840235 | The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycemic control, inflammation, kidney function, and expression of PPAR-α, PPAR-γ, TGF-β, and Nrf-2 genes in patients with diabetic nephropathy: A triple-blinded, randomized, placebo-controlled trial |
| Orange | 📋 | | ⛔ | | 37469434 | Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers |
| Paeoniflorin | 📋 | | | | 36510583 | Paeoniflorin, a constituent of Kami-shoyo-san, suppresses blood glucose levels in postmenopausal diabetic mice by promoting the secretion of estradiol from adipocytes |
| Peony | 📋 | | ⛔ | | 37648027 | Antidiabetic and antioxidant properties of Paeonia mascula L.: In vitro and in vivo studies, and phytochemical analysis |
| Pine Bark | 📋 | ✍ | ⛔ | | 31099529 | Pycnogenol® Prevents Oxidative Stress and Side Effects in Patients With Hypothyroidism During Levothyroxine Treatment |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 29061705 | Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice |
| Punicalagin | 📋 | ✍ | ⛔ | | 35412829 | Punicalagin Attenuates Neuronal Apoptosis by Upregulating 5-Hydroxymethylcytosine in the Diabetic Mouse Brain |
| Red Clover | 📋 | ✍ | ⛔ | | 35164615 | Trifolium pratense extract increases testosterone and improves sperm characteristics and antioxidant status in diabetic rats |
| Rice | 📋 | | ⛔ | | 36105966 | Alpha glucosidase inhibitory properties of a few bioactive compounds isolated from black rice bran: combined in vitro and in silico evidence supporting the antidiabetic effect of black rice |
| Rosmarinic Acid | 📋 | ✍ | | | 37662743 | Rosemarinic acid protects β-cell from STZ-induced cell damage via modulating NF-κβ pathway |
| Royal Jelly | 📋 | ✍ | ⛔ | | 38474777 | Royal Jelly and Fermented Soy Extracts-A Holistic Approach to Menopausal Symptoms That Increase the Quality of Life in Pre- and Post-menopausal Women: An Observational Study |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 34161166 | Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 34497854 | Comparison between the Antioxidant and Antidiabetic Activity of Fenugreek and Buckthorn in Streptozotocin-Induced Diabetic Male Rats |
| Spearmint | 📋 | | ⛔ | | 32197626 | A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS |
| Trehalose | 📋 | | ⛔ | | 35330193 | Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in db/ db Diabetic Mice |
| Valerian Root | 📋 | ✍ | ⛔ | | 37160299 | Effect of Fennel-Valerian Extract on Hot Flashes and Sleep Disorders in Postmenopausal Women: A Randomized Trial |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 38368515 | The Effects of Thiamine Supplementation on General Health and Infertility Treatment Outcomes in Women with Polycystic Ovary Syndrome: A Triple-Blinded Randomized Placebo-Controlled Clinical Trial |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37147641 | Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites |
| Acacetin | 📋 | | | | 35780455 | Acacetin antagonized lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress |
| Aged Garlic | 📋 | ✍ | ⛔ | | 33803601 | S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells |
| Antioxidants | 📋 | | ⛔ | | 38251706 | Efficacy of antioxidant supplementation in improving endocrine, hormonal, inflammatory, and metabolic statuses of PCOS: a meta-analysis and systematic review |
| Apple Polyphenols | 📋 | | ⛔ | | 35222800 | Effects of Annurca Flesh Apple Polyphenols in Human Thyroid Cancer Cell Lines |
| Avocado Oil | 📋 | | ⛔ | | 35889863 | Effects of Avocado Oil Supplementation on Insulin Sensitivity, Cognition, and Inflammatory and Oxidative Stress Markers in Different Tissues of Diet-Induced Obese Mice |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 34900813 | In-vivo and in-vitro evaluation of therapeutic potential of β- Carotene in diabetes |
| Bilberry | 📋 | ✍ | ⛔ | | 34996690 | Phytochemical and pharmacological anti-diabetic properties of bilberries (Vaccinium myrtillus), recommendations for future studies |
| Cherry | 📋 | | ⛔ | | 36038032 | Effects of tart cherry juice consumption on cardio-metabolic risk factors: a systematic review and meta-analysis of randomized-controlled trials |
| Chia Seeds | 📋 | | ⛔ | | 38138560 | Chia ( Salvia hispanica L.), a Pre-Hispanic Food in the Treatment of Diabetes Mellitus: Hypoglycemic, Antioxidant, Anti-Inflammatory, and Inhibitory Properties of α-Glucosidase and α-Amylase, and in the Prevention of Cardiovascular Disease |
| Creatine | 📋 | ✍ | ⛔ | | 31952174 | Long-Term Effect of Combination of Creatine Monohydrate Plus β-Hydroxy β-Methylbutyrate (HMB) on Exercise-Induced Muscle Damage and Anabolic/Catabolic Hormones in Elite Male Endurance Athletes |
| Dandelion | 📋 | ✍ | ⛔ | | 35326230 | Combination Effects of Metformin and a Mixture of Lemon Balm and Dandelion on High-Fat Diet-Induced Metabolic Alterations in Mice |
| Dihydroquercetin | 📋 | | | | 34572963 | Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance via the miR-195/IRS1/PI3K/AKT and AMPK Signalling Pathways |
| Essential Oils | 📋 | | ⛔ | | 38003691 | Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications |
| Fiber | 📋 | ✍ | ⛔ | | 37960272 | Longitudinal Associations of Dietary Fiber Intake with Glycated Hemoglobin and Estimated Insulin Sensitivity in Adults with and without Type 1 Diabetes |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 37405785 | Effect of Fucoxanthin on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 34116484 | Increased pro-inflammatory cytokines in ovary and effect of γ-linolenic acid on adipose tissue inflammation in a polycystic ovary syndrome model |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 37115805 | Glycyrrhizin ameliorates impaired glucose metabolism and ovarian dysfunction in a polycystic ovary syndrome mouse model |
| Guggul | 📋 | ✍ | ⛔ | | 37516016 | In-vivo anti-diabetic and anti-hyperlipidemic effects of natural metabolites from resin of Commiphora mukul and their in-silico to in-vitro target fishing |
| Hawthorn | 📋 | ✍ | ⛔ | | 35711333 | Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in Underlying of Diabetes: A Review |
| Honokiol | 📋 | | | | 38659261 | Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells |
| Inulin | 📋 | ✍ | ⛔ | | 35902903 | Inulin reduces visceral adipose tissue mass and improves glucose tolerance through altering gut metabolites |
| Iron | 📋 | ✍ | ⛔ | | 38004184 | Relationship between Iron Deficiency and Thyroid Function: A Systematic Review and Meta-Analysis |
| L-Glutamine | 📋 | ✍ | ⛔ | | 37109458 | Repurposing Pitavastatin and L-Glutamine: Replenishing β-Cells in Hyperlipidemic Type 2 Diabetes Mouse Model |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 34763302 | Linoleic acid and the regulation of glucose homeostasis: A review of the evidence |
| Liquiritin | 📋 | | | | 35733703 | Protective effects of liquiritin on polycystic ovary syndrome through modulating ovarian granulosa cell proliferation and apoptosis via miR-206/PI3K/AKT pathway |
| Magnolia | 📋 | ✍ | ⛔ | | 36067838 | Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221 |
| Milk Thistle | 📋 | ✍ | ⛔ | | 33047319 | Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity |
| Millet | 📋 | | | | 37814770 | Managing Diabetes Mellitus With Millets: A New Solution |
| Morin | 📋 | | | | 38091524 | Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high-fat diet-fed mice |
| Mushrooms | 📋 | | ⛔ | | 36590224 | Mushroom polysaccharides with potential in anti-diabetes: Biological mechanisms, extraction, and future perspectives: A review |
| Pomegranate Seed extract | 📋 | | ⛔ | | 35257560 | The effect of pomegranate seed oil on human health, especially epidemiology of polycystic ovary syndrome; a systematic review |
| Pumpkin | 📋 | | ⛔ | | 37398913 | Evaluation of Antidiabetic and Antioxidant Activities of Fruit Pulp Extracts of Cucurbita moschata Duchesne and Cucurbita maxima Duchesne |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 38397839 | Evaluation of Antioxidant Effects of Pumpkin ( Cucurbita pepo L.) Seed Extract on Aging- and Menopause-Related Diseases Using Saos-2 Cells and Ovariectomized Rats |
| Schisandrins | 📋 | | | | 37495090 | Schisandrin B, a potential GLP-1R agonist, exerts anti-diabetic effects by stimulating insulin secretion |
| Soybean Oil | 📋 | | ⛔ | | 34039393 | Effects of increasing intake of soybean oil on synthesis of testosterone in Leydig cells |
| Star Fuit | 📋 | | ⛔ | | 32606871 | Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway |
| Tanshinone | 📋 | | | | 38640337 | Role and molecular mechanism of Salvia miltiorrhiza associated with chemical compounds in the treatment of diabetes mellitus and its complications: A review |
| Tetrahydrocurcumin | 📋 | ✍ | | | 27482294 | Curcumin and Tetrahydrocurcumin Both Prevent Osteoarthritis Symptoms and Decrease the Expressions of Pro-Inflammatory Cytokines in Estrogen-Deficient Rats |
| Theabrownins | 📋 | | | | 38563324 | Theabrownin from Fu Brick tea ameliorates high-fat induced insulin resistance, hepatic steatosis, and inflammation in mice by altering the composition and metabolites of gut microbiota |
| Trans-Resveratrol | 📋 | | | | 34371884 | Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 37351031 | Combined Ursolic Acid and Resistance/Endurance Training Improve Type 3 Diabetes Biomarkers-Related Memory Deficits in Hippocampus of Aged Male Wistar Rats |
| Vitamins | 📋 | | | | 37637683 | Effect of vitamin supplementation on polycystic ovary syndrome and key pathways implicated in its development: A Mendelian randomization study |
| White Tea | 📋 | | ⛔ | | 34369381 | Effect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized rats |
| Yogurt | 📋 | | ⛔ | | 36774230 | Yogurt Supplementation Attenuates Insulin Resistance in Obese Mice by Reducing Metabolic Endotoxemia and Inflammation |
| Asiaticoside | 📋 | | | | 38599249 | Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies |
| Aspirin | 📋 | | ⛔ | | 37713477 | Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease and Diabetes Mellitus: A Subgroup Analysis of the ADAPTABLE Trial |
| Astragalin | 📋 | | | | 35411464 | Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression |
| Barberry | 📋 | ✍ | ⛔ | | 32132921 | Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases |
| Basil | 📋 | ✍ | ⛔ | | 32700851 | Two Cultivars of Ocimum basilicum Leaves Extracts Attenuate Streptozotocin-mediated Oxidative Stress in Diabetic Rats |
| Bay Leaf | 📋 | | ⛔ | | 36881915 | Evaluation of daily Laurus nobilis tea consumption on anxiety and stress biomarkers in healthy volunteers |
| BCAA | 📋 | ✍ | ⛔ | | 36177954 | Peripheral fatigue and hormone responses to branched-chain amino acids ingestion and exercise in recovery: a systematic review and meta-analysis |
| Berries | 📋 | | | | 31775396 | An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults |
| Bilobalide | 📋 | | | | 33959665 | Bilobalide Enhances AMPK Activity to Improve Liver Injury and Metabolic Disorders in STZ-Induced Diabetes in Immature Rats via Regulating HMGB1/TLR4/NF- κ B Signaling Pathway |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 35871254 | Frankincense extract protects against testicular damage through augmentation of antioxidant defense mechanisms and modulation of apoptotic genes expression |
| Broccoli | 📋 | | ⛔ | | 35348219 | Broccoli microgreens have hypoglycemic effect by improving blood lipid and inflammatory factors while modulating gut microbiota in mice with type 2 diabetes |
| Buckwheat | 📋 | | ⛔ | | 36016679 | Tartary Buckwheat Flavonoids Improve Colon Lesions and Modulate Gut Microbiota Composition in Diabetic Mice |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 36926656 | Modulatory effect of caffeic acid in alleviating diabetes and associated complications |
| Calycosin | 📋 | | | | 36588732 | Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells |
| Carnosic Acid | 📋 | | | | 35408495 | Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake |
| Carvacrol | 📋 | ✍ | ⛔ | | 38154959 | Carvacrol improves blood lipid and glucose in rats with type 2 diabetes mellitus by regulating short-chain fatty acids and the GPR41/43 pathway |
| Catalpol | 📋 | | | | 35905692 | Catalpol attenuates polycystic ovarian syndrome by regulating sirtuin 1 mediated NF-κB signaling pathway |
| Chicory | 📋 | ✍ | ⛔ | | 36219736 | Effects of Chicory and Fumitory on Hot Flashes Among Breast Cancer Survivors: A Randomized, Double-Blind Placebo-Controlled Trial |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 38674824 | Conjugated Linoleic Acid Ameliorates High Fat-Induced Insulin Resistance via Regulating Gut Microbiota-Host Metabolic and Immunomodulatory Interactions |
| Crocetin | 📋 | | | | 38004168 | Identification of Crocetin as a Dual Agonist of GPR40 and GPR120 Responsible for the Antidiabetic Effect of Saffron |
| Dioscin | 📋 | | | | 38154275 | Dioscin: Therapeutic potential for diabetes and complications |
| Eucommia | 📋 | ✍ | ⛔ | | 36335171 | Testosterone promotion effect of Eucommia ulmoides staminate flower via the steroidogenic pathway and potential hormonal mechanism |
| Fish | 📋 | | ⛔ | | 38584675 | Association between Fish Intake and Serum Testosterone Levels in Older Males: The Hitachi Health Study II |
| Forskolin | 📋 | ✍ | ⛔ | | 33804418 | Effect of Forskolin on Body Weight, Glucose Metabolism and Adipocyte Size of Diet-Induced Obesity in Mice |
| Galangin | 📋 | | | | 30862104 | Discovery of Galangin as a Potential DPP-4 Inhibitor That Improves Insulin-Stimulated Skeletal Muscle Glucose Uptake: A Combinational Therapy for Diabetes |
| Geniposide | 📋 | | | | 34856473 | A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4 |
| Glycine | 📋 | ✍ | ⛔ | | 35052658 | GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study |
| Goat Milk | 📋 | | ⛔ | | 37990402 | Goat Milk Improves Glucose Metabolism in Type 2 Diabetic Mice and Protects Pancreatic β-Cell Functions |
| Gotu Kola | 📋 | ✍ | ⛔ | | 34326888 | Ethanolic Extract of Centella asiatica Treatment in the Early Stage of Hyperglycemia Condition Inhibits Glomerular Injury and Vascular Remodeling in Diabetic Rat Model |
| Gymnema Sylvestre | 📋 | ✍ | ⛔ | | 38107140 | Unlocking the anti-diabetic potential of Gymnema sylvestre, Trigonella foenum-graecum, and their combination thereof: An in-vivo evaluation |
| Haritaki | 📋 | ✍ | ⛔ | | 37240813 | Treatment with Terminalia chebula Extract Reduces Insulin Resistance, Hyperglycemia and Improves SIRT1 Expression in Type 2 Diabetic Rats |
| Helichrysum | 📋 | | ⛔ | | 35631811 | Helichrysum Genus and Compound Activities in the Management of Diabetes Mellitus |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 37795159 | The Comparative Study of the Administration of the Combination Preparation of Isoflavones and Hyaluronic Acid in Menopausal Women for the Treatment of the Symptoms of Menopause, Urogenital Atrophy and Oteoporosis in Relation to Existing Hormone Replacement Therapies |
| Hypericin | 📋 | | | | 34454929 | Anti-cancer impact of Hypericin in B-CPAP cells: Extrinsic caspase dependent apoptosis induction and metastasis obstruction |
| L-Carnosine | 📋 | ✍ | ⛔ | | 38172006 | Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial |
| L-Leucine | 📋 | ✍ | ⛔ | | 37972527 | High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women |
| Lactobacillus plantarum | 📋 | | ⛔ | | 27757592 | Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice |
| Lauric Acid | 📋 | ✍ | | | 37211320 | Lauric acid improves hormonal profiles, antioxidant properties, sperm quality and histomorphometric changes in testis and epididymis of streptozotocin-induced diabetic infertility rats |
| Lavender | 📋 | ✍ | ⛔ | | 37970441 | Synergic effects of Trigonella foenum-graecum, Ribes rubrum, Lavandula angustifolia, and Arctium Lappa extracts mixture on learning and memory deficits in streptozocin-induced diabetic rats |
| Lettuce | 📋 | | ⛔ | | 35889834 | Evaluation of the Effectiveness of Fermented Soybean-Lettuce Powder for Improving Menopausal Symptoms |
| Ligustilide | 📋 | | | | 38061285 | Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells |
| Loquat | 📋 | ✍ | ⛔ | | 35718052 | Loquat (Eriobotrya japonica (Thunb) Lindl.): Evaluation of nutritional value, polyphenol composition, antidiabetic effect, and toxicity of leaf aqueous extract |
| Lutein | 📋 | ✍ | ⛔ | | 37207866 | Lutein Targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy |
| Milk | 📋 | | ⛔ | | 38342541 | Mechanisms by which sheep milk consumption ameliorates insulin resistance in high-fat diet-fed mice |
| Myricetin | 📋 | | ⛔ | | 38520750 | Myricetin ameliorates polycystic ovary syndrome in mice by brown adipose tissue activation |
| Neem | 📋 | ✍ | | | 35198760 | Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica A. Juss. flower in the stressed rats |
| Nuts | 📋 | | ⛔ | | 36127725 | Nut consumption is associated with a shift of the NMR lipoprotein subfraction profile to a less atherogenic pattern among older individuals at high CVD risk |
| Parthenolide | 📋 | | | | 37095470 | Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 18662395 | The effects of phosphatidylserine on endocrine response to moderate intensity exercise |
| Polydatin | 📋 | ✍ | | | 37175783 | The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance |
| Prickly Pear | 📋 | | ⛔ | | 37054824 | Protective effects and mechanisms of opuntia polysaccharide in animal models of diabetes mellitus: A systematic review and meta-analysis |
| Procyanidins | 📋 | | ⛔ | | 32659127 | Screening active components from Rubus amabilis for pancreatic β-cells protection |
| Progesterone | 📋 | ✍ | ⛔ | | 37047801 | Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines |
| Psyllium | 📋 | ✍ | ⛔ | | 35769394 | Effect of Psyllium husk fiber and lifestyle modification on human body insulin resistance |
| Rapamycin | 📋 | ✍ | | | 36580373 | Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes |
| Red Sage | 📋 | ✍ | ⛔ | | 38640337 | Role and molecular mechanism of Salvia miltiorrhiza associated with chemical compounds in the treatment of diabetes mellitus and its complications: A review |
| Rehmannia | 📋 | ✍ | ⛔ | | 35694255 | Antidiabetic Effect of Rehmanniae Radix Based on Regulation of TRPV1 and SCD1 |
| Sesame | 📋 | ✍ | ⛔ | | 37689713 | Vitamin D improves the antidiabetic effectiveness of aerobic training via modulation of Akt, PEPCK, and G6Pase expression |
| Sesame Oil | 📋 | | ⛔ | | 36810739 | Ameliorative effect of sesame oil on experimentally induced polycystic ovary syndrome: A cross-link between XBP-1/PPAR-1, regulatory proteins for lipogenesis/steroids |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 34359426 | Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial |
| Shilajit | 📋 | ✍ | ⛔ | | 37697053 | Do "testosterone boosters" really increase serum total testosterone? A systematic review |
| Shogaol | 📋 | | | | 36766032 | Effects of 6-Shogaol on Glucose Uptake and Intestinal Barrier Integrity in Caco-2 Cells |
| Soy Protein | 📋 | ✍ | ⛔ | | 38174000 | Protein supplementation: the double-edged sword |
| Sweet Potato | 📋 | | ⛔ | | 37025833 | White-skinned sweet potato ( Ipomoea batatas L.) acutely suppresses postprandial blood glucose elevation by improving insulin sensitivity in normal rats |
| Tomato | 📋 | | ⛔ | | 38583186 | Does tomato juice consumption have a positive effect on the physical and psychological states of individuals in the Coronavirus era? |
| Urolithins | 📋 | | | | 36589826 | Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 37754210 | Increased Dietary Niacin Intake Improves Muscle Strength, Quality, and Glucose Homeostasis in Adults over 40 Years of Age |
| Withaferin A | 📋 | | | | 35608923 | In-silico validation of novel therapeutic activities of withaferin a using molecular docking and dynamics studies |
| 5-HTP | 📋 | ✍ | ⛔ | | 31091223 | Rumen-Protected 5-Hydroxytryptophan Improves Sheep Melatonin Synthesis in the Pineal Gland and Intestinal Tract |
| Alfalfa | 📋 | | ⛔ | | 38257240 | Evaluating the Antioxidant and Antidiabetic Properties of Medicago sativa and Solidago virgaurea Polyphenolic-Rich Extracts |
| Allicin | 📋 | ✍ | ⛔ | | 38044730 | [Effects of allicin on insulin resistance and free fatty acid levels in obese rats with periodontitis] |
| Amaranth | 📋 | | ⛔ | | 35717911 | Identification of antidiabetic peptides derived from in silico hydrolysis of three ancient grains: Amaranth, Quinoa and Chia |
| Anethole | 📋 | | | | 36029056 | The Protective Effects of Trans-Anethole against Polycystic Ovary Syndrome Induced Histopathological and Metabolic Changes in Rat |
| Anise | 📋 | ✍ | ⛔ | | 31724151 | Aqueous anise extract alleviated the pancreatic changes in streptozotocin-induced diabetic rat model via modulation of hyperglycaemia, oxidative stress, apoptosis and autophagy: a biochemical, histological and immunohistochemical study |
| Anthocyanidins | 📋 | | | | 36436987 | Anthocyanins and Curcumin: Possible Abilities of Prevention of Diabetes and Obesity via Stimulation of Glucagon-Like Peptide-1 Secretion and Induction of Beige Adipocyte Formation |
| Arjuna | 📋 | ✍ | ⛔ | | 35739183 | Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats |
| Artichoke | 📋 | ✍ | ⛔ | | 38102588 | Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and GSK-3β signaling pathway |
| Baicalein | 📋 | ✍ | ⛔ | | 38518646 | Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta |
| Beer | 📋 | | | | 37402233 | Effect of moderate beer consumption (with and without ethanol) on cardiovascular health in postmenopausal women |
| Beets | 📋 | ✍ | ⛔ | | 35461298 | Effect of red beetroot juice on oxidative status and islet insulin release in adult male rats |
| Bergamot | 📋 | ✍ | ⛔ | | 37732063 | Metabolic and vascular effect of a new standardized bergamot phytocomplex: a three-arm, placebocontrolled, double-blind clinical trial |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 34333586 | Effect of Carnosine or β-Alanine Supplementation on Markers of Glycemic Control and Insulin Resistance in Humans and Animals: A Systematic Review and Meta-analysis |
| Beta-Cryptoxanthin | 📋 | | | | 28689061 | β-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-κB and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 36106930 | Oat β-glucan and L-arabinose synergistically ameliorate glucose uptake in insulin-resistant HepG2 cells and exert anti-diabetic activity via activation of the PI3K/AKT pathway in db/db mice |
| Betulinic Acid | 📋 | | | | 36070616 | Betulinic acid improves TNF- α-induced insulin resistance by inhibiting negative regulator of insulin signalling and inflammation-activated protein kinase in 3T3-L1 adipocytes |
| Black Pepper | 📋 | ✍ | ⛔ | | 25862960 | Uncovering potential of Indonesian medicinal plants on glucose uptake enhancement and lipid suppression in 3T3-L1 adipocytes |
| Boric Acid | 📋 | ✍ | ⛔ | | 38689139 | In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells |
| Burdock | 📋 | | ⛔ | | 37970441 | Synergic effects of Trigonella foenum-graecum, Ribes rubrum, Lavandula angustifolia, and Arctium Lappa extracts mixture on learning and memory deficits in streptozocin-induced diabetic rats |
| Camellia | 📋 | | ⛔ | | 38606255 | Modulation of Oxidative Stress and Glycemic Control in Diabetic Wistar Rats: The Therapeutic Potential of Theobroma cacao and Camellia sinensis Diets |
| Carrot | 📋 | | ⛔ | | 30608159 | Origin of Hypoglycemic Benefits of Probiotic-Fermented Carrot Pulp |
| Casein Protein | 📋 | ✍ | ⛔ | | 37798798 | Effects of supplementation with milk protein on glycemic parameters: a GRADE-assessed systematic review and dose-response meta-analysis |
| Cashew | 📋 | | ⛔ | | 37255827 | Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes |
| Cat's Claw | 📋 | ✍ | ⛔ | | 21718770 | Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 34920751 | Inonotus obliquus polysaccharide ameliorates serum profiling in STZ-induced diabetic mice model |
| Citrus Fruits | 📋 | | ⛔ | | 35796456 | Effect of Citrus Flavanones on Diabetes; A Systematic Review |
| Clove | 📋 | | ⛔ | | 37183845 | The Effects of Clove Oil on The Biochemical and Histological Parameters, and Autophagy Markers in Polycystic Ovary Syndrome-Model Rats |
| Costus | 📋 | ✍ | ⛔ | | 38253277 | Metabolomic insights into the therapeutic mechanisms of costus (Saussurea costus (Falc.) Lipsch.) root extract in propylthiouracil-induced hypothyroidism rat model |
| D-Ribose | 📋 | ✍ | ⛔ | | 35684021 | A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD + Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial |
| Echinacea | 📋 | ✍ | ⛔ | | 36613632 | Ameliorative Effect of Ethanolic Echinacea purpurea against Hyperthyroidism-Induced Oxidative Stress via AMRK and PPAR Signal Pathway Using Transcriptomics and Network Pharmacology Analysis |
| Elderberry | 📋 | ✍ | ⛔ | | 38662754 | Ameliorative effects of elderberry (Sambucus nigra L.) extract and extract-derived monosaccharide-amino acid on H2O2-induced decrease in testosterone-deficiency syndrome in a TM3 Leydig cell |
| Equol | 📋 | ✍ | ⛔ | | 34506596 | Effects of an equol-containing supplement on advanced glycation end products, visceral fat and climacteric symptoms in postmenopausal women: A randomized controlled trial |
| Fermented Foods | 📋 | | ⛔ | | 37799064 | Fermented soybean foods and diabetes |
| Fish Collagen | 📋 | ✍ | ⛔ | | 37367668 | Fish-Derived Protein Hydrolysates Increase Insulin Sensitivity and Alter Intestinal Microbiome in High-Fat-Induced Obese Mice |
| Fruits | 📋 | | | | 34792409 | Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication? |
| Galangal | 📋 | ✍ | ⛔ | | 36120365 | DPHB, a diarylheptane from Alpinia officinarum Hance, ameliorates insulin resistance: A network pharmacology and in vitro study |
| Geranium | 📋 | | | | 35170422 | Effect of Pelargonium graveolens on Glucose Metabolism in Streptozotocin-Induced Diabetic Rats |
| Geranium Essential Oil | 📋 | | ⛔ | | 28326753 | Effects of essential oil exposure on salivary estrogen concentration in perimenopausal women |
| Glabridin | 📋 | | | | 25816349 | Estrogenicity of glabridin in Ishikawa cells |
| Glucosamine | 📋 | ✍ | ⛔ | | 34082859 | Ameliorative Effects of Oral Glucosamine on Insulin Resistance and Pancreatic Tissue Damage in Experimental Wistar rats on a High-fat Diet |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 25599391 | Helichrysum and Grapefruit Extracts Boost Weight Loss in Overweight Rats Reducing Inflammation |
| Hops | 📋 | ✍ | ⛔ | | 36333646 | Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice |
| Hyperoside | 📋 | | | | 37984122 | Hypericum perforatum L. protects against renal function decline in ovariectomy rat model by regulating expressions of NOS3 and AKT1 in AGE-RAGE pathway |
| Isoliquiritigenin | 📋 | | | | 35114453 | Isoliquiritigenin alleviates diabetic symptoms via activating AMPK and inhibiting mTORC1 signaling in diet-induced diabetic mice |
| Jujube | 📋 | | ⛔ | | 34237667 | Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data |
| Kombucha | 📋 | ✍ | ⛔ | | 34744740 | The Efficacy and Safety of Multiple Dose Regimens of Kudzu ( Pueraria lobata) Root Extract on Bone and Cartilage Turnover and Menopausal Symptoms |
| Krill Oil | 📋 | ✍ | ⛔ | | 29157255 | Effects of Antarctic Krill Oil on Lipid and Glucose Metabolism in C57BL/6J Mice Fed With High Fat Diet |
| L-Alanine | 📋 | ✍ | ⛔ | | 36125865 | Coadministration of L-alanine and L-glutamine ameliorate blood glucose levels, biochemical indices and histological features in alloxan-induced diabetic rats |
| L-Lysine | 📋 | ✍ | ⛔ | | 38004100 | Arginine and Lysine Supplementation Potentiates the Beneficial β-Hydroxy ß-Methyl Butyrate (HMB) Effects on Skeletal Muscle in a Rat Model of Diabetes |
| Lingonberry | 📋 | | ⛔ | | 29888863 | Lingonberry Extract Provides Neuroprotection by Regulating the Purinergic System and Reducing Oxidative Stress in Diabetic Rats |
| Lychee | 📋 | | ⛔ | | 35179169 | Litchi chinensis seed prevents obesity and modulates the gut microbiota and mycobiota compositions in high-fat diet-induced obese zebrafish |
| Madecassoside | 📋 | | | | 38599249 | Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies |
| Mango | 📋 | | ⛔ | | 36986450 | Antidiabetic and Anticancer Potentials of Mangifera indica L. from Different Geographical Origins |
| Mastic | 📋 | ✍ | ⛔ | | 37796709 | Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils |
| MSM | 📋 | ✍ | ⛔ | | 35708633 | Methylsulfonylmethane and Sesame Seed Oil Improve Dyslipidemia and Modulate Polyunsaturated Fatty Acid Metabolism in Two Mouse Models of Diabetes |
| Neferine | 📋 | | | | 35794985 | Neferine Exerts Ferroptosis-Inducing Effect and Antitumor Effect on Thyroid Cancer through Nrf2/HO-1/NQO1 Inhibition |
| Oleanolic Acid | 📋 | | | | 37255809 | Effect of Oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes |
| Olive Polyphenols | 📋 | | | | 33561976 | Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review |
| Oolong Tea | 📋 | | ⛔ | | 35321328 | Special Thai Oolong Tea: Chemical Profile and In Vitro Antidiabetic Activities |
| Patchouli | 📋 | ✍ | ⛔ | | 37071615 | Preventive Activity of Patchouli Alcohol Against Colorectal Cancer and Diabetes |
| Pectin | 📋 | ✍ | ⛔ | | 36756885 | Pectin mediates the mechanism of host blood glucose regulation through intestinal flora |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 32944877 | Supplementation of fenugreek with choline-docosahexaenoic acid attenuates menopause induced memory loss, BDNF and dendritic arborization in ovariectomized rats |
| Piperlongumine | 📋 | | | | 37175755 | Piperlongumine Induces Cellular Apoptosis and Autophagy via the ROS/Akt Signaling Pathway in Human Follicular Thyroid Cancer Cells |
| PUFA | 📋 | | | | 35297549 | A low n-6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinemia by restoring insulin clearance in obese youth |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 21545273 | Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study |
| Quercitrin | 📋 | | | | 37321077 | Quercitrin alleviates lipid metabolism disorder in polycystic ovary syndrome-insulin resistance by upregulating PM20D1 in the PI3K/Akt pathway |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 37111106 | Effects of Monacolin K in Nondiabetic Patients with NAFLD: A Pilot Study |
| Rosehip | 📋 | ✍ | ⛔ | | 32180815 | Molecular mechanism of the anti-diabetic activity of an identified oligosaccharide from Rosa canina |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 31353725 | Ameliorative impact of cold-pressed Rosmarinus officinalis oil against liver toxicity and genotoxic effects in streptozotocin-induced diabetic rats and their offspring |
| Safranal | 📋 | | | | 37324874 | Comparison of the effect of saffron, crocin, and safranal on serum levels of oxidants and antioxidants in diabetic rats: A systematic review and meta-analysis of animal studies |
| Salt | 📋 | | ⛔ | | 34084229 | The effect of salt supplements on thyroid hormones and quality of pregnancy in female hypothyroid rats |
| Salvianolic Acid | 📋 | | | | 34636119 | Dissection of the potential anti-diabetes mechanism of salvianolic acid B by metabolite profiling and network pharmacology |
| Sea Cucumber | 📋 | | | | 37909356 | Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca2+/PKA signaling pathway |
| Sesamin | 📋 | ✍ | | | 37407302 | Sesamin alleviated fluoride - induced thyroid endocrine disruption in zebrafish (Danio rerio) |
| Sesamol | 📋 | | | | 37885753 | Sesamol combats diabetogenic effects of atorvastatin through GLUT-4 expression and improved pancreatic viability |
| Skullcap | 📋 | ✍ | ⛔ | | 34737007 | The root extract of Scutellaria baicalensis Georgi promotes β cell function and protects from apoptosis by inducing autophagy |
| Stigmasterol | 📋 | | | | 28970778 | Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
| Sunflower | 📋 | | ⛔ | | 37324929 | Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females |
| Syringic Acid | 📋 | | | | 34610616 | Dietary syringic acid reduces fat mass in an ovariectomy-induced mouse model of obesity |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37525894 | Tannic Acid Ameliorates Systemic Glucose and Lipid Metabolic Impairment Induced by Low-Dose T-2 Toxin Exposure |
| Tea | 📋 | | | | 35066640 | Differential impact of cold and hot tea extracts on tyrosine phosphatases regulating insulin receptor activity: a focus on PTP1B and LMW-PTP |
| Telmisartan | 📋 | | ⛔ | | 37576807 | Telmisartan versus metformin in downregulating myostatin gene expression and enhancing insulin sensitivity in the skeletal muscles of type 2 diabetic rat model |
| Thyme | 📋 | ✍ | ⛔ | | 35320013 | A Complex of Cirsium japonicum var. maackii (Maxim.) Matisum. and Thymus vulgaris L. Improves Menopausal Symptoms and Supports Healthy Aging in Women |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 35463673 | The Therapeutic Effect of Coriolus versicolor Fruiting Body on STZ-Induced ICR Diabetic Mice |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 18520055 | Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 36432448 | Biotin Enhances Testosterone Production in Mice and Their Testis-Derived Cells |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 37235778 | Vitamin K1 Intake and Incident Diabetes in the Danish Diet, Cancer, and Health Study |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 35662764 | The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 21914161 | Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells |
| Vitexin | 📋 | | | | 33935599 | Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications |
| Wine | 📋 | | ⛔ | | 33053742 | Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans |
| Yerba Mate | 📋 | ✍ | ⛔ | | 37514235 | Dietary Supplementation with Yerba Mate ( Ilex paraguariensis) Infusion Increases IRS-1 and PI3K mRNA Levels and Enhances Insulin Sensitivity and Secretion in Rat Pancreatic Islets |
| Acai Berry | 📋 | ✍ | ⛔ | | 33621858 | Dietary anthocyanin-rich extract of açai protects from diet-induced obesity, liver steatosis, and insulin resistance with modulation of gut microbiota in mice |
| Acemannan | 📋 | | | | 37776926 | Acemannan ameliorates STZ-activated diabetes by attenuating high glucose via inhibiting inflammatory cytokines and apoptosis pathway |
| Activated Charcoal | 📋 | ✍ | ⛔ | | 35634388 | Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice |
| Aloesin | 📋 | | | | 26265996 | Aloesin as a Medical Food Ingredient for Systemic Oxidative Stress of Diabetes |
| Alpha GPC | 📋 | ✍ | ⛔ | | 30582404 | Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-Ay mice |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 20211645 | Higher Dietary Intake of Alpha-Linolenic Acid Is Associated With Lower Insulin Resistance in Middle-Aged Japanese |
| Amino Acids | 📋 | | | | 34420200 | Effect of Vitamin-Containing Amino Acid Supplements on Menopausal Symptoms and Age-Related Skin Changes: A Randomised, Double-Blind, Placebo-Controlled Study |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 32825073 | A Combination of Apple Vinegar Drink with Bacillus coagulans Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis |
| Apricot Kernels | 📋 | ✍ | ⛔ | | 33645417 | Consumption of bitter apricot seeds affects lipid and endocrine profile in women |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 35982452 | Syntaxin interacts with arachidonic acid to prevent diabetes mellitus |
| Arctigenin | 📋 | | | | 36481528 | Arctigenin mitigates insulin resistance by modulating the IRS2/GLUT4 pathway via TLR4 in type 2 diabetes mellitus mice |
| Artemisinin | 📋 | | | | 37036874 | Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway |
| Ashitaba | 📋 | ✍ | ⛔ | | 23596719 | [Effects of angelica keiskei chalcone on expression of glucose transporter proteins in liver and skeletal muscle cells of type 2 diabetic rats] |
| Asparagus | 📋 | | ⛔ | | 37755852 | Beneficial Effects of Asparagus officinalis Extract Supplementation on Muscle Mass and Strength following Resistance Training and Detraining in Healthy Males |
| Atractylodes | 📋 | ✍ | ⛔ | | 36067838 | Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221 |
| Banana | 📋 | | ⛔ | | 36200727 | Diet supplemented with boiled unripe plantain (Musa paradisiaca) exhibited antidiabetic potentials in streptozotocin-induced Wistar rats |
| Bean | 📋 | | ⛔ | | 28372224 | Black Bean Anthocyanin-Rich Extracts as Food Colorants: Physicochemical Stability and Antidiabetes Potential |
| Bee Pollen | 📋 | ✍ | ⛔ | | 33555077 | Synergic effect of bee pollen and metformin on proliferation and apoptosis of granulosa cells: Rat model of polycystic ovary syndrome |
| Bee Venom | 📋 | ✍ | ⛔ | | 36618290 | Serological and Histological Evaluation of the Effect of Honeybee Venom on Pancreas and Liver in Diabetic Mice |
| Bell Pepper | 📋 | | ⛔ | | 37446918 | Effects of Capsaicin on Glucose Uptake and Consumption in Hepatocytes |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 25824404 | Effects of bergamot ( Citrus bergamia (Risso) Wright & Arn.) essential oil aromatherapy on mood states, parasympathetic nervous system activity, and salivary cortisol levels in 41 healthy females |
| Camphor | 📋 | ✍ | ⛔ | | 33084110 | Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan-induced diabetic rats by camphor |
| Carnosol | 📋 | | | | 36786429 | Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation |
| Celery | 📋 | | ⛔ | | 34062080 | The effect of Apium graveolens L., Levisticum officinale and Calendula officinalis L. on cell viability, membrane integrity, steroidogenesis, and intercellular communication in mice Leydig cells in vitro |
| Chickpea | 📋 | | ⛔ | | 37977304 | Integrating serum pharmacochemistry and network pharmacology to reveal the mechanism of chickpea in improving insulin resistance |
| Chitosan | 📋 | ✍ | ⛔ | | 36547931 | Antidiabetic Properties of Chitosan and Its Derivatives |
| Chondroitin | 📋 | ✍ | ⛔ | | 35667460 | Chondroitin sulfate stimulates the secretion of H 2 S by Desulfovibrio to improve insulin sensitivity in NAFLD mice |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 34858550 | Lomens-P0 (mixed extracts of Hordeum vulgare and Chrysanthemum zawadskii) regulate the expression of factors affecting premenstrual syndrome symptoms |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 35164117 | Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations |
| Citicoline | 📋 | ✍ | ⛔ | | 25589288 | Cardioprotective properties of citicoline against hyperthyroidism-induced reperfusion damage in rat hearts |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 30012894 | Phytochemical Compositions and Antidiabetic Potentials of Salvia sclarea L. Essential Oils |
| Clove Essential Oil | 📋 | | ⛔ | | 35212917 | Syzygium aromaticum bud (clove) essential oil is a novel and safe aldose reductase inhibitor: in silico, in vitro, and in vivo evidence |
| Copper | 📋 | ✍ | ⛔ | | 34358885 | Dietary copper and selenium are associated with insulin resistance in overweight and obese Malaysian adults |
| Coriander | 📋 | | ⛔ | | 33477662 | Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 35326092 | Coriander Oil Reverses Dexamethasone-Induced Insulin Resistance in Rats |
| Corn Silk | 📋 | ✍ | ⛔ | | 35673494 | Anti-diabetic potential of Corn silk ( Stigma maydis): An in-silico approach |
| Cryptotanshinone | 📋 | | | | 37879506 | Mechanism of cryptotanshinone to improve endocrine and metabolic functions in the endometrium of PCOS rats |
| Cucumber | 📋 | | ⛔ | | 33214339 | Cucumis sativus and Cucurbita maxima extract attenuate diabetes-induced hepatic and pancreatic injury in a rat model |
| Cumin | 📋 | | ⛔ | | 35608174 | Phytochemical screening of ethanolic extracts of Cuminum cyminum L. seeds along with the evaluation of antidiabetic properties by molecular docking approach |
| Cyanidin | 📋 | ✍ | | | 35357376 | Antihyperglycemic effect of an anthocyanin, cyanidin-3- O-glucoside, is achieved by regulating GLUT-1 via the Wnt/β-catenin-WISP1 signaling pathway |
| D-Mannose | 📋 | ✍ | ⛔ | | 34886901 | ZIP10 is a negative determinant for anti-tumor effect of mannose in thyroid cancer by activating phosphate mannose isomerase |
| Deodar Cedar | 📋 | | | | 36690306 | Cedrus deodara (Roxb. ex D.Don) G.Don bark fraction ameliorates metabolic, endocrine and ovarian dynamics in rats experiencing polycystic ovarian syndrome |
| Diallyl Disulfide | 📋 | | | | 38042045 | Effects of diallyl disulfide administration on insulin resistance in high-fat diet-fed mice |
| Diallyl Sulfide | 📋 | | | | 18972399 | Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats |
| Diallyl Trisulfide | 📋 | | | | 33751676 | Diallyl trisulphide, a H 2 S donor, compromises the stem cell phenotype and restores thyroid-specific gene expression in anaplastic thyroid carcinoma cells by targeting AKT-SOX2 axis |
| Dihydroartemisinin | 📋 | | | | 35663306 | Dihydroartemisinin Exerts Antifibrotic and Anti-Inflammatory Effects in Graves' Ophthalmopathy by Targeting Orbital Fibroblasts |
| Diosmetin | 📋 | | | | 34091150 | Diosmetin ameliorate type 2 diabetic mellitus by up-regulating Corynebacterium glutamicum to regulate IRS/PI3K/AKT-mediated glucose metabolism disorder in KK-Ay mice |
| Docosapentaenoic Acid | 📋 | ✍ | | | 27860326 | Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets |
| Echinacoside | 📋 | | | | 38336255 | Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway |
| Egg | 📋 | | ⛔ | | 37686779 | Consumption of Different Egg-Based Diets Alters Clinical Metabolic and Hematological Parameters in Young, Healthy Men and Women |
| Eleuthero | 📋 | ✍ | ⛔ | | 15507373 | Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice |
| Escin | 📋 | ✍ | ⛔ | | 28378396 | The positive clinical therapeutically effects of Escin on advanced thyroid cancer |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 35050206 | Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice |
| Eurycomanone | 📋 | | | | 23810842 | Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis |
| Fennel Essential Oil | 📋 | ✍ | ⛔ | | 38139998 | Fennel Essential Oil as a Complementary Therapy in the Management of Diabetes |
| Fluted Gourd | 📋 | | | | 21709398 | Inhibition of the experimental induction of benign prostatic hyperplasia: a possible role for fluted pumpkin (Telfairia occidentalis Hook f.) seeds |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 32781739 | The Root of Polygonum multiflorum Thunb. Alleviates Non-Alcoholic Steatosis and Insulin Resistance in High Fat Diet-Fed Mice |
| Formononetin | 📋 | | | | 22922276 | Formononetin attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells |
| Ganoderic Acid | 📋 | | | | 27649729 | Comparison of the Chemical Profiles and Antioxidant and Antidiabetic Activities of Extracts from Two Ganoderma Species (Agaricomycetes) |
| Giloy | 📋 | ✍ | ⛔ | | 37901891 | Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model |
| Ginkgolic Acid | 📋 | | | | 30153591 | Ginkgolic acid as a dual-targeting inhibitor for protein tyrosine phosphatases relevant to insulin resistance |
| Ginkgolides | 📋 | | | | 20105177 | The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex |
| Glycyrrhetinic Acid | 📋 | | | | 38346790 | Natural Sweetener Glycyrrhetinic Acid Monoglucuronide Improves Glucose Homeostasis in Healthy Mice |
| Grape Seed Oil | 📋 | | ⛔ | | 23506314 | Does grape seed oil improve inflammation and insulin resistance in overweight or obese women? |
| Hemp Oil | 📋 | ✍ | ⛔ | | 37704445 | Prophylactic Effects of Hemp Seed Oil on Perimenopausal Depression: A Role of HPA Axis |
| Indian Barberry | 📋 | ✍ | ⛔ | | 31888241 | Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial |
| Isoquercitrin | 📋 | | | | 34626776 | Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway |
| Isorhamnetin | 📋 | | | | 36842967 | Isorhamnetin inhibits inflammatory response to alleviate DHEA-induced polycystic ovary syndrome in rats |
| Jasmine | 📋 | | ⛔ | | 35685730 | Integrating In Silico and In Vitro Approaches to Screen the Antidiabetic Properties from Tabernaemontana divaricata (Jasmine) Flowers |
| Kiwifruit | 📋 | ✍ | ⛔ | | 26060538 | Hypoglycemic and antioxidant effects of Daraesoon (Actinidia arguta shoot) in animal models of diabetes mellitus |
| Knotweed | 📋 | ✍ | ⛔ | | 31289648 | Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes |
| L-Histidine | 📋 | ✍ | ⛔ | | 33000160 | l-Histidine Supplementation in Adults and Young Children with Atopic Dermatitis (Eczema) |
| L-Methionine | 📋 | ✍ | ⛔ | | 33457340 | The Effects of Zinc Methionine on Reproductive and Thyroid Hormones in Rats with Polycystic Ovarian Syndrome |
| L-Theanine | 📋 | ✍ | ⛔ | | 15877297 | Cortitrol supplementation reduces serum cortisol responses to physical stress |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 15996691 | Surplus dietary tryptophan reduces plasma cortisol and noradrenaline concentrations and enhances recovery after social stress in pigs |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 37743153 | The effect of aromatherapy massage with lemon and peppermint essential oil on menopausal symptoms: A double-blinded, randomized placebo controlled clinical trial |
| Lemon Verbena | 📋 | | ⛔ | | 35011093 | Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract |
| Lemongrass | 📋 | ✍ | ⛔ | | 32736056 | Cymbopogon citratus (DC.) Stapf mitigates ER-stress induced by streptozotocin in rats via down-regulation of GRP78 and up-regulation of Nrf2 signaling |
| Lentil | 📋 | | ⛔ | | 36122501 | Eight weeks of lentil consumption attenuates insulin resistance progression without increased gastrointestinal symptom severity: A randomized clinical trial |
| Licochalcones | 📋 | | | | 37850242 | Licochalcone A alleviates abnormal glucolipid metabolism and restores energy homeostasis in diet-induced diabetic mice |
| Linalool | 📋 | | ⛔ | | 15684505 | Effects of inhaling the vapor of Lavandula burnatii super-derived essential oil and linalool on plasma adrenocorticotropic hormone (ACTH), catecholamine and gonadotropin levels in experimental menopausal female rats |
| Liquiritigenin | 📋 | | | | 18778944 | Screening of herbal constituents for aromatase inhibitory activity |
| Long Pepper | 📋 | | ⛔ | | 36469428 | Anti-diabetic effects and molecular mechanisms of amide alkaloids from Piper longum based on network pharmacology integrated with cellular assays |
| Lovage | 📋 | | ⛔ | | 32922483 | Antidiabetic Properties of Hydroalcoholic Leaf and Stem Extract of Levisticum officinale: An implication for α-amylase Inhibitory Activity of Extract Ingredients through Molecular Docking |
| Magnolol | 📋 | | | | 34833990 | Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus |
| Malvidin | 📋 | | | | 34416477 | Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies |
| Mandarin | 📋 | | | | 33105861 | Efficacy and Safety of Kudzu Flower-Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial |
| Manganese | 📋 | ✍ | ⛔ | | 37409718 | Protective effect of manganese treatment on insulin resistance in HepG2 hepatocytes |
| Marigold | 📋 | ✍ | ⛔ | | 35845946 | The Effect of Hydroalcoholic Calendula Officinalis Extract on Androgen-Induced Polycystic Ovary Syndrome Model in Female Rat |
| Marjoram | 📋 | | ⛔ | | 32877649 | The ameliorative effects of marjoram in dehydroepiandrosterone induced polycystic ovary syndrome in rats |
| Mint | 📋 | | ⛔ | | 37496047 | Exploring the antibacterial, antidiabetic, and anticancer potential of Mentha arvensis extract through in-silico and in-vitro analysis |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 27551476 | Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 33015880 | Effect of myrtle (Myrtus communis L.) essential oil on oxidant-antioxidant balance in rats with propylthiouracil-induced hypothyroidism |
| NAD | 📋 | | | | 34056649 | NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome‡ |
| Nattokinase | 📋 | ✍ | ⛔ | | 34359426 | Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 25024731 | Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial |
| Nitrate | 📋 | ✍ | ⛔ | | 36622081 | Independent, but not co-supplementation with nitrate and resveratrol improves glucose tolerance and reduces markers of cellular stress in high-fat-fed male mice |
| Noni | 📋 | | ⛔ | | 37794521 | Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance |
| Nuciferine | 📋 | | | | 35755273 | Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway |
| Nutmeg | 📋 | ✍ | ⛔ | | 31063201 | Ameliorative effect of Myristica fragrans (nutmeg) extract on oxidative status and histology of pancreas in alloxan induced diabetic rats |
| Oleic Acid | 📋 | | ⛔ | | 33631425 | Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species / JUN Pathway |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 32848717 | Computational and Pharmacological Evaluation of Carveol for Antidiabetic Potential |
| Oregano | 📋 | ✍ | ⛔ | | 36098212 | Oregano as a potential source of antidiabetic agents |
| Oyster | 📋 | | ⛔ | | 36097247 | Effects of Aerobic Exercise Combined with Oyster Peptide Supplement on the Formation of CTX-induced Late-Onset Hypogonadism in Male Rats |
| Paeonol | 📋 | | | | 38493906 | Paeonol alleviates postmenopause-induced neuropsychiatric symptoms through the modulation of GPR30 in ovariectomized mice |
| Pantethine | 📋 | ✍ | ⛔ | | 2359503 | [Evaluation of the cholesterol-lowering effectiveness of pantethine in women in perimenopausal age] |
| Parsley | 📋 | | ⛔ | | 34497857 | Antioxidant Potential of Parsley Leaf ( Petroselinum crispum) Essential Oil on Hypothyroidism and Testicular Injury in Mice Intoxicated by Carbon Tetrachloride |
| PEA | 📋 | ✍ | ⛔ | | 35176443 | Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice |
| Peach | 📋 | | ⛔ | | 34522198 | Antidiabetic potential of the isolated fractions from the plants of Rosaceae family in streptozotocin-induced diabetic rats |
| Peanut | 📋 | | ⛔ | | 34482855 | The association between insulin resistance and the consumption of nut including peanut, pine nut and almonds in working-aged Korean population |
| Peas | 📋 | | ⛔ | | 38156281 | Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 37743153 | The effect of aromatherapy massage with lemon and peppermint essential oil on menopausal symptoms: A double-blinded, randomized placebo controlled clinical trial |
| Perilla | 📋 | ✍ | | | 34579018 | Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and Metabolic Disturbance in Obese-Insulin-Resistant Rats |
| Phellodendron | 📋 | ✍ | ⛔ | | 16454147 | Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial |
| Phloretin | 📋 | | | | 38243397 | Phloretin: a comprehensive review of its potential against diabetes and associated complications |
| Phytosterols | 📋 | | | | 35268696 | A Comprehensive Review on Therapeutic Perspectives of Phytosterols in Insulin Resistance: A Mechanistic Approach |
| Pine Nut | 📋 | | ⛔ | | 34482855 | The association between insulin resistance and the consumption of nut including peanut, pine nut and almonds in working-aged Korean population |
| Pistachio | 📋 | ✍ | ⛔ | | 35795961 | Effects of pistachios on glycemic control: A systematic review and meta-analysis of randomized controlled trials |
| Potassium | 📋 | ✍ | ⛔ | | 33499915 | A nutrient pattern characterized by vitamin A, C, B6, potassium, and fructose is associated with reduced risk of insulin-related disorders: A prospective study among participants of Tehran lipid and glucose study |
| Potato | 📋 | | ⛔ | | 36117546 | Potato consumption is not associated with cardiometabolic health outcomes in Framingham Offspring Study adults |
| PQQ | 📋 | ✍ | ⛔ | | 38095308 | The Potential Role of Pyrroloquinoline Quinone to Regulate Thyroid Function and Gut Microbiota Composition of Graves' Disease in Mice |
| Protein | 📋 | ✍ | ⛔ | | 37972527 | High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 35678366 | Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K |
| Rapeseed Oil | 📋 | ✍ | | | 33514384 | The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: a randomized controlled trial |
| Retinoic Acid | 📋 | | | | 34417575 | All-trans retinoic acid impairs glucose-stimulated insulin secretion by activating the RXR/SREBP-1c/UCP2 pathway |
| Rhodiola | 📋 | ✍ | ⛔ | | 31069710 | Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase |
| Rhubarb | 📋 | | ⛔ | | 36788517 | The effects of aqueous and ethanolic extracts of Rheum ribes on insulin-resistance and apolipoproteins in patients with type 2 diabetes mellitus: a randomized controlled trial |
| Rose | 📋 | | | | 35605922 | Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats |
| Safflower | 📋 | ✍ | ⛔ | | 34487844 | Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial |
| Sage Essential Oil | 📋 | | ⛔ | | 30372910 | Metabolic impairments and tissue disorders in alloxan-induced diabetic rats are alleviated by Salvia officinalis L. essential oil |
| SAMe | 📋 | ✍ | ⛔ | | 30582404 | Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-Ay mice |
| Sandalwood Essential Oil | 📋 | | ⛔ | | 34664591 | Sandalwood seed oil improves insulin sensitivity in high-fat/high-sucrose diet-fed rats associated with altered intestinal microbiota and its metabolites |
| Seafood | 📋 | | | | 36235539 | Thyroidal and Extrathyroidal Requirements for Iodine and Selenium: A Combined Evolutionary and (Patho)Physiological Approach |
| Seaweeds | 📋 | | ⛔ | | 38068845 | Brown Seaweed Consumption as a Promising Strategy for Blood Glucose Management: A Comprehensive Meta-Analysis |
| Senolytics | 📋 | | | | 35432205 | Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells |
| Sirtuin Activators | 📋 | | | | 36225477 | Role of Sirtuins in Diabetes and Age-Related Processes |
| Sorghum | 📋 | | ⛔ | | 34572963 | Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance via the miR-195/IRS1/PI3K/AKT and AMPK Signalling Pathways |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 29399556 | Role of Essential Oil of Mentha Spicata (Spearmint) in Addressing Reverse Hormonal and Folliculogenesis Disturbances in a Polycystic Ovarian Syndrome in a Rat Model |
| Spermidine | 📋 | | | | 35255928 | Effect of spermidine on ameliorating spermatogenic disorders in diabetic mice via regulating glycolysis pathway |
| Spices | 📋 | | | | 31703341 | Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening |
| Star Anise | 📋 | ✍ | ⛔ | | 37612867 | Antidiabetic Effect of Star Anise (Illicium Verum) in Streptozotocin-induced Diabetic Rats |
| Sugarcane | 📋 | | ⛔ | | 33123536 | Sugarcane ( Saccharum officinarum L.) Top Extract Ameliorates Cognitive Decline in Senescence Model SAMP8 Mice: Modulation of Neural Development and Energy Metabolism |
| Tea Polyphenols | 📋 | | | | 36821039 | Tea Polyphenols Reduce Inflammation of Orbital Fibroblasts in Graves' Ophthalmopathy via the NF-κB/NLRP3 Pathway |
| Thymol | 📋 | ✍ | ⛔ | | 27761760 | Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway |
| Turnip | 📋 | | ⛔ | | 34886781 | Aqueous Extract of Brassica rapa Exerts Antihyperglycemic Activity in Streptozotocin-induced Diabetic Rats |
| Vegetables | 📋 | | | | 35836691 | Increased vegetable intake improves glycaemic control in adults with type 2 diabetes mellitus: a clustered randomised clinical trial among Indonesian white-collar workers |
| Vitamin B Complex | 📋 | | ⛔ | | 15790610 | Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 27983705 | Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development |
| Vitamin K | 📋 | ✍ | ⛔ | | 33454929 | A critical review of the effects of vitamin K on glucose and lipid homeostasis: its potential role in the prevention and management of type 2 diabetes |
| Water Chestnut | 📋 | ✍ | ⛔ | | 33532353 | Antidiabetic and anticancer activity of Chinese water chestnut ( Eleocharis dulcis) extract with multistage extraction |
| Watercress | 📋 | ✍ | ⛔ | | 36351033 | Nasturtium officinale L. and metformin alleviate the estradiol -induced polycystic ovary syndrome with synergistic effects through modulation of Bax/Bcl-2/p53/caspase-3 signaling pathway and anti-inflammatory and anti-oxidative effects |
| Withanolides | 📋 | | | | 30854916 | A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males |
| Yam | 📋 | | | | 37600377 | Integrating network pharmacology and experimental studies for uncovering the molecular mechanisms of Dioscorea bulbifera L. in the treatment of thyroid cancer |
| Yohimbine | 📋 | ✍ | | | 34345380 | Effects of intraperitoneal and intracerebroventricular injection of cinnamaldehyde and yohimbine on blood glucose and serum insulin concentrations in ketamine-xylazine induced acute hyperglycemia |
